Preparation of 4,4'-Dihydroxy-3,3'-dinitrobenzophenone

4,4'-dihydroxy-3,3'-dinitrobenzophenone was synthesized from chlorobenzene and chlorobenzoyl chloride through three-step reactions,which were Friedel-Crafts acylation reaction,nitration reaction by mixed acid,and alkaline hydrolysis reaction in alcohol-water medium. The total yield of 4,4'-dihydroxy-3,3'-dinitrobenzophenone was 78. 34%. FTIR,MS,1HNMR and HPLC were used to characterize and analyze the structure and purity of the products. Single factor experiment was used to study the process of alkaline hydrolysis reaction in order to determine the optimum conditions,under which the yield of the crude product was 96. 71%,and its purity was 97. 11%. In order to obtain a purer product,DMF and isopropanol were used to recrystallize the crude product,which improved the purity of product to 99. 30% and generated a recrystallization yield of 81%.