Scabronines B, C, D, E and F, novel diterpenoids showing stimulating activity of nerve growth factor-synthesis, from the mushroom Sarcodon scabrosus

Abstract Novel cyathane-type diterpenoids, scabronines B – F (1 – 5) were isolated from the mushroom Sarcodon scabrosus . Their structures were determined by interpretation of their spectral data and chemical transformation. The absolute stereochemistry of scabronine C (2) was confirmed by the exciton chirality method, and the chemical transformation of scabronines B, C and D (1, 2 and 3) clarified their absolute structures. The absolute stereochemistries of scabronines E and F (4 and 5) were determined by comparison of their CD spectra with that of erinacine A (7). Among these compounds, scabronines B, C and E (1, 2 and 4) exhibit stimulating activity of the synthesis of a nerve growth factor.