Correlation of quantitative parameters of dynamic contrast-enhanced MRI with subtypes of breast carcinoma

Objective To explore the quantitative parameters on dynamic contrast-enhanced MRI(DCE-MRI) in patients with different subtypes of breast carcinoma,and to observe the correlation between the parameters and prognostic factors of breast cancers.Methods Totally 78 patients with pathologically proved infiltrating breast carcinoma who underwent DCE-MRI before treatment and quantitative parameters(Ktrans,Kep and Ve) were measured.Estrogen recepter(ER),progesterone receptor(PR) and human epidermalgrowth factor receptor-2(HER-2) were obtained by immunohistochemistry,and then the subtype of every case was decided.The association between parameters and subtypes,as well as prognostic factors were analyzed.Results Among 68 available cases,24 were Luminal A,19 were Luminal B,10 were HER-2+ and 15 were triple-negative breast cancer(TNBC).Kep was significantly different among the four subtypes(P0.01).Ktrans,Kep and Ve were significantly different between Luminal A and TNBC(all P0.05).Among the four subtypes,TNBC had higher Ktrans and Kep and lower Ve.Kep was higher in tumors with ER-than ER+,and Kep was also higher in tumors with PR-than PR+.Ktrans was significantly different between PR-and PR+.Conclusion The differentiation of Luminal A and TNBC by Ktrans,Kep and Ve is applicable.Kep is associated with subtypes of breast cancers and prognostic factors,including ER and PR.