First Total Synthesis of (+)-11-Hydroxyerythratidine

The first total synthesis of (+)-11 -hydroxyerythratidine is described. The strategy is featured by a highly stereoselective construction of the C(5) spiro center via the Lewis acid promoted cyclization of ortho-quinone acetal, derived from di-ortho-substituted biphenyl 9 with a chiral center at the side chain.