Physiological effects of an open lung ventilatory strategy titrated on elastance-derived end-inspiratory transpulmonary pressure: study in a pig model*.

Rationale:In the presence of increased chest wall elastance, the airway pressure does not reflect the lung-distending (transpulmonary) pressure.Objective:To compare the physiological effects of a conventional open lung approach titrated for an end-inspiratory airway opening plateau pressure (30 cm H