Implication of Silver Nanoparticles to Enhance the Potential Therapeutic Activity of Doum Palm (Hyphaene Thebaica) Extract for in vitro Sperm Activation of Asthenozoospermic Infertile Men

Male infertility is a worldwide public health issue which affected a significant proportion of humanity. Many herbs extracts have been well documented as a therapy for infertility. This study has uniquely examined for the first time, the role of the bioactive effect of Doum Palm extract using silver nanoparticles (NPs) on improving the sperm motility of infertile human male. Semen samples of ten patients diagnosed with asthenozoospermia were collected. Semen samples were collected from ten voluntary normozoospermic males used as positive control. Doum Palm extract with and/or without silver NPs was investigated using In vitro sperm activation layering technique. The present study has demonstrated that there was a significant (p<0.05) effect of Doum Palm extract with and without using silver NPs on active sperm motility when compared with control semen samples. Interestingly, this study has found that the application of silver NPs as a drug delivery vehicles for Doum Palm extract has a significant implication on enhancing the sperm motility in vitro. This finding suggested that the implication of NPs technology in assisted reproductive techniques (ARTs) may have a great future on improving sperm quality.