[Expression and clinical significance of gastric dramatic down-related gene in gastric cancer and precancerous lesions].

Objective To investigate the expression and clinical significance of gastric dramatic down-related gene( GDDR) in gastric cancer and precancerous lesion tissues. Methods Immunohistochemical staining was performed to detect the expression of GDDR in 240 cases of gastric tissues,including 40 cases of normal gastric mucosa( NGM),40 cases of chronic superficial gastritis( CSG),40 cases of chronic atrophic gastritis( CAG),40 cases of intestinal metaplasia( IM),20 cases of mild dysplasia( MD),20 cases of severe dysplasia( SD) and 40 cases of gastric cancer( GC). Results The mean rank order of GDDR were 190. 70,182. 70,146. 24,104. 40,70. 33,47. 20 and 40. 20 in NGM,CSG,CAG,IM, MD,SD and GC,respectively. The expression of GDDR significantly decreased in CAG,IM,MD,SD and GC as compared with normal controls and CSG( P 0. 01). Conclusion The gradually down-regulated expression of GDDR is an early molecular event in the development of gastric cancer. GDDR may play an important role in the early diagnosis of gastric cancer and may be utilized as a molecular diagnostic marker and a new target of anti-tumor molecular therapy in early stage of gastric cancer.