T2011 Confocal Laser Endomicroscopy Allows In Vivo Differentiation Between Adenomatous and Non-Adenomatous Colorectal Polyps

Cyclin-Dependent Kinase Inhibitor 2A (CDKN2A) was increased with PPARα deletion and in polyps compared to normal mucosa whilst that of the renal carcinoma cell (RCC) gene was reduced in APC Min/+ PPARα -/-. Conclusions. The genotype of APC Min/+ PPARα -/mice is compatible with loss of PPARα -/function and impacts on genes that may alter susceptibility to polyp formation Fold changes in gene expression associated with PPARα deletion