Evaluation of Immunosuppressive Acidic Protein (IAP) in Patient with Oral Cancer

Serum IAP levels were examined in 24 patients with oral cancer and 31 patients with benign oral disease (tumor and cystic lesion) as a control, in the Second Department of Oral Surgery, Kyushu Dental College Hospital, during the period from 1982 to 1984. The following results were obtained:1) Serum IAP levels in patients with oral cancer were 566.9±100.9 μg/ml and 66. 7% of these were in a level over 500 μg/ml. In squamous cell carcinoma, serum IAP levels were 595. 7±101. 5 μg/ml and 72. 7% of these were in a level over 500 μg/ml. Therefore, serum IAP levels in patients with oral cancer were higher with statistical significance (p<0. 01) than those in the controls.2) Serum IAP levels increased gradually in accordance with the progress of the oral cancer.3) Serum IAP levels in good prognosis cases were 406.4 ±92. 8 μg/ml and in poor prognosis cases were 808. 9±230. 9 μg/ml (p<0. 01). In good prognosis cases, it was observed in patients with the reduction of high IAP level. On the other hand, serum IAP levels in poor prognosiscases showed a tendency to increase gradually.4) In these investigations, it was suggested that the determination of serum IAP is useful in evaluating the progress of oral cancer, the effects of treatment and prognosis in oral cancer patients.