Patterns of Relapse Following Focal Irradiation of Intracranial Germinoma: Critical Review of TGM-TC90 SFOP protocol

In the SFOP protocol TGM-TC90 for localised tumours, craniospinal (CS) prophylactic radiotherapy fields were replaced by carboplatin-based chemotherapy together with focal irradiation of the initial tumour volume (40 Gy). Metastatic tumours received CS irradiation and a local boost. In order to refine radiation-treatment volumes, patterns of relapse with respect to radiation technique were documented.