IN-VIVO ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF

The present investigation deals with the in-vivo acute toxicity studies and in-vivo anti-inflammatory activity by Carrageenan induced rat paw edema model of methanolic extract in the stems of Cissus pallida. The Literature review reveals the presence of steroids, flavonoids, triterpenoids, and glycosides in Cissus pallida. Some plants belonging to Cissus genus have been reported to posses anti-inflammatory activity hence methanolic extract of stems of C. pallida were screened for anti-inflammatory activity. Carrageenan induced significant inflammation when compared with the animals treated with the extracts. Standard drug, indomethacin at 10 mg/kg inhibited the inflammation significantly at all time intervals. C.pallida exhibited significant anti-inflammatory activity in dose dependant manner. C.pallida inhibited the carrageenan induced inflammation significantly at doses of 500 and 1000 mg/kg at 2, 3, 4 and 5 hours.