Randomized study of single early instillation of (2r)-4-o-tetrahydropyranyl-doxorubicin for a single superficial bladder carcinoma.

Background: Although transurethral resection of a bladder tumor (TUR-BT) alone has been standard treatment for single superficial bladder carcinoma, some authors reported a certain prophylactic effect of a single immediate intravesical instillation of chemotherapeutic agent after TUR-BT. A prospective randomized study was conducted to determine whether a single (2R)-4-O-tetrahydropyranyl-doxorubicin (THP) instillation immediately after TUR-BT is beneficial to patients with a single superficial bladder carcinoma.