Pharmacological management of neuropathic pain in non-specialist settings: summary of NICE guidance

Neuropathic pain is often difficult to treat as it is resistant to many medications and effective medications often have adverse effects. Its estimated prevalence is between 1% and 2% in the United Kingdom.1 Treatment practice is thought to vary considerably throughout the UK in terms of starting treatment, achievement of therapeutic doses, and correct sequencing of therapeutic classes, thus probably leading in some cases to inadequate pain control, with considerable morbidity. This article summarises the most recent recommendations from the National Institute for Health and Clinical Excellence (NICE) on drug management for neuropathic pain in adults in primary and secondary care, excluding specialist pain services.2 NICE recommendations are based on systematic reviews of best available clinical and cost effectiveness evidence. When minimal evidence is available, recommendations are based on the Guideline Development Group’s experience and opinion of what constitutes good practice including, in this guidance, lessons derived from other clinically relevant fields. Evidence levels for the recommendations are given in italic in square brackets. The following definitions apply to this guideline: ### Key principles of care