Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C > T have a prognostic value in acute myeloid leukemia

Kerstin Willander,Ingrid Jakobsen-Falk,Roza Chaireti,Esbjorn Paul,Monica Hermansson,Henrik Gréen,Kourosh Lotfi,Peter Söderkvist

Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C > T have a prognostic value in acute myeloid leukemia

2014

Kerstin Willander
Ingrid Jakobsen-Falk
Roza Chaireti
Esbjorn Paul
Monica Hermansson
Henrik Gréen
Kourosh Lotfi
Peter Söderkvist

Background The isocitrate dehydrogenase (IDH1/IDH2) genes are metabolic enzymes, which are frequently mutated in acute myeloid leukemia (AML). The enzymes acquire neomorphic enzymatic activity when they mutated.

Keywords:

Enzyme
IDH2
Myeloid leukemia
Isocitrate dehydrogenase
Gene
Medical genetics
IDH1
Cancer research
Bioinformatics
Medicine
SNP

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