Using topic modeling via non-negative matrix factorization to identify relationships between genetic variants and disease phenotypes: A case study of Lipoprotein(a) (LPA)
2019
Genome-wide and phenome-wide association studies are commonly used to identify important relationships between genetic variants and phenotypes. Most of these studies have treated diseases as independent variables and suffered from heavy multiple adjustment burdens due to the large number of genetic variants and disease phenotypes. In this study, we propose using topic modeling via non-negative matrix factorization (NMF) for identifying associations between disease phenotypes and genetic variants. Topic modeling is an unsupervised machine learning approach that can be used to learn the semantic patterns from electronic health record data. We chose rs10455872 in LPA as the predictor since it has been shown to be associated with increased risk of hyperlipidemia and cardiovascular diseases (CVD). Using data of 12,759 individuals from the biobank at Vanderbilt University Medical Center, we trained a topic model using NMF from 1,853 distinct phecodes extracted from the cohort9s electronic health records and generated six topics. We quantified their associations with rs10455872 in LPA. Topics indicating CVD had positive correlations with rs10455872 (P
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
40
References
0
Citations
NaN
KQI