Nephrotic syndrome during treatment with alpha-mercaptopropionylglycine.
1979
We report 2 cases of cystinuria in which, a nephrotic syndrome developed during treatment with alpha-mercaptopropionylglycine. This syndrome resolved after withdrawal of the drug and it did not recur when the alpha-mercaptopropionylglycine was given again in lower doses. The hypothesis is made that the nephrotic syndrome was dose-related. The aipha-mercaptopropionylglycine must be used in doses <50 mg./kg. per day with regular monitoring of 24-hour urinary protein in cystinuric children.
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