Chronic Active Ulcerative Colitis

Chronic moderately to severely active UC is a heterogeneous disease in which the incorporation of biomarkers into the baseline assessment plays an important role in understanding the individual disease phenotype. Disease activity should be proactively monitored with the non-invasive biomarkers CRP and faecal calprotectin, in addition to endoscopic assessment to establish mucosal and histological severity. Serial faecal calprotectins are particularly useful in UC and can be used to predict risk of disease flare and to titrate treatment. Cumulative inflammatory burden increases risk of dysplasia and should be considered over disease duration when assessing risk of colorectal cancer.