Biodegradable Temperature- and pH Dually-responsive Poly(β-amino ester)

Stimuli-responsive polymers have undoubtedly been of great interest in the past few decades due to a variety of potential applications in biomedical territory but their non-degradability limits their in vivo applications. Herein, we report a novel dual-stimuli responsive pH- and temperature-responsive poly(β-amino ester). The pH/temperature sensitivities are interrelated and can be easily tuned by the PEG-diacrylate chain length and the percentage of biamines in the feed ratio. These dually-responsive polymers are very useful in drug delivery.