First one thousand families: Our multidisciplinary experience in the heredo-familial cancer unit from a Spanish University Hospital.

1556 Background: Patients with hereditary cancer syndromes (HCS) need a multidisciplinary approach: Different organs and systems may be involved and different risk reducing strategies (medical and surgical) should be provided. In 2010 we implemented a multidisciplinary heredo-familial cancer unit (HFCU) in Hospital General Universitario Gregorio Maranon (Madrid, Spain). Methods: A retrospective analysis of the first 1000 families attended in our HFCU (2010-2014). Results: 1167 patients, from 1000 different families were attended. 929 patients (79.6%) fulfilled international criteria for HCS; 84 are pending of gathering more information. Genetic test results were available for 426 patients, with 136 cases bearing pathological mutations. New mutation detection rate (first time diagnosis in a family) was 44/235 (18.7%). Two patients with no HCS criteria were diagnosed with BRCA1 and MSH2 mutations respectively. For the 136 patients with a pathological mutation, prophylactic surgery and /or follow up were off...