ATILIPIDEMIC ACTIVITY OF CISSUS QUADRAGULARIS AD TRIBULUS TERRESTRIS OOBESITY IHIGH FAT FED RATS

Summary The present study was designed to investigate the comparative effect of ethanol extract of Cissus quadrangularis and Tribulus terrestris on lipid profile in rats. Plant extract was orally administered to high fat fed rats (ghee + normal feed in the ratio 2:1) at a dose of 583 mg / kg body weight for 30 days. At the end of the experiment the animals were sacrificed and biochemical analysis of serum was performed for cholesterol, phospholipids, HDL and TG. The increased in cholesterol level, Phospholipids, HDL and TG were brought to some what normal by oral administration of Cissus quadrangularis and Tribulus terrestris . The histopathological examination of liver and heart showed positive result. The results of biochemical observations were supplemented by histipathological examination of rat’s heart and liver section. The data suggested that oral administrtion with Cissus quadrangularis and Tribulus terrestris for 30 days has significantly antihyperlipidemic effect against high fat fed rats.