Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase

Yili Ding,Kenneth L. Smith,Chamakura V.N.S. Varaprasad,Eugene Chang,John Alexander,Nanhua Yao

Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase

2007

Yili Ding
Kenneth L. Smith
Chamakura V.N.S. Varaprasad
Eugene Chang
John Alexander
Nanhua Yao

Abstract Several thiazolone-based sulfonamides were prepared, utilizing various hetero-aryl sulfonyl chlorides and different aldehydes, as inhibitors of NS5B polymerase, to target HCV. The best compound showed 0.6 nM of IC 50 inhibitory activity.

Keywords:

Enzyme
Chemical synthesis
NS5B
Hepatitis C virus
Polymerase
Enzyme inhibitor
Sulfonyl
Biochemistry
Chemistry
Nucleotidyltransferase
ns5b polymerase
In vitro

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