Aggressive regional therapy vs conventional treatment of patients with unresected liver metastases from colorectal cancer: A multivariate analysis focused on overall survival

3675 Background: The prognosis of unresected colorectal (CRC) liver metastases is poor. Most patients receive systemic chemotherapy or supportive care only. There is suggested survival benefit with aggressive regional treatment such as hepatic artery infusion (HAI), radiofrequency ablation (RFA), and cryosurgical ablation (CSA). We have analyzed various therapies for unresected liver metastases to determine survival impact. Methods: Survival was analyzed in 173 patients with hepatic metastases from CRC according to variables of: site (colon vs rectum) and stage of the primary tumor (ages +/− 65 years), gender, timing of metastases (synchronous vs metachronous), extent of metastatic disease (regional vs regional plus extra hepatic), and type of treatment. The latter included primary tumor resection (yes/no), systemic therapy vs supportive care, and treatment of liver metastases by regional therapy (HAI,RFA,CSA) vs systemic therapy or supportive care. Survival results were compared by univariate and multiva...