Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

Bile acids exert metabolic effects by modulating FXR receptor activity. Here, Trabelsi et al. show that FXR negatively regulates production of the incretin GLP-1 in enteroendocrine L-cells by reducing glycolysis and that inhibition of FXR improves glucose metabolism by increasing GLP-1 in obese mice.