Protective Effect of Methylene Blue on Neuronal Damage Induced by Okadaic Acid in Differentiated SK-N-SH Neuroblastoma Cells

Objective: To investigate the protective effects and the underlying mechanism of methylene blue (MB) on neuronal damage induced by okadaic acid (OA). Methods: The SK-N-SH neuroblastoma cells were differentiated into mature neurons by all-trans retinoic acid (ATRA) and the differentiation index was successfully verified. The Alzheimer's disease model was established by OA treatment as the toxic effects to mature neurons. 基金项目:国家自然科学基金面上项目(11175222);石河子大学重大科技攻关计划项目(gxjs2012-zdgg02); 山东省泰山学者建设工程专项经费(tshw201502046)。 作者简介:佀营营(1989—),女,硕士研究生,研究方向为食品营养与健康。E-mail: 15253518423@163.com *通信作者:王振华(1973—),男,副教授,博士,研究方向为自由基生物医学。E-mail: zhenhuawang@tom.com 2016-01-25