Effects of non-surgical periodontal treatment on the l-arginine-nitric oxide pathway and oxidative status in platelets
2013
Several studies have suggested an increase of cardiovascular disease (CVD) risk on periodontitis patients. An enhancement has been demonstrated on both platelet activation and oxidative stress on periodontitis patients, which may contribute for this association. Therefore, the aim of this study was to evaluate the effects of non-surgical periodontal treatment on the l-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway and oxidative status in platelets. A total of eight periodontitis patients and eight controls were included in this study. Clinical, laboratory and experimental evaluations were performed on baseline and 90 days after periodontal treatment (except for western blot analysis). The clinical periodontal evaluation included measurements of probing pocket depth (PPD), clinical attachment loss (CAL), % of sites with plaque and % of sites with bleeding on probing. We evaluated: l-[3H]arginine influx; nitric oxide synthase (NOS) and arginase enzymes activity and expression; expr...
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
54
References
10
Citations
NaN
KQI