Risk factors of cardiorenal syndrome type 1 in patients with acute myocardial infarction

Objectives To investigate the risk factors of cardiorenal syndrome type 1 (CRS1) in patients with acute myocardial infarction (AMI). Methods The medical date of hospitalized patients with AMI from January, 2013 to February, 2014 in Hunan Provincial People's Hospital were reviewed. A total of 265 patients with AMI was divided into CRS1 and non-CRS1 groups. The univariate comparison and multivariate Logistic regression analysis were performed to obtain the CRS1 risk factors. Results In the 265 AMI patients, CRS1 was found in 59 patients (22.3%). Age, history of diabetes, Killip classification, left ventricular ejection fraction (LVFF), baseline serum creatinine, blood urea nitrogen, uric acid, baseline evaluated glomerular filtration rate (eGFR), serum sodium, the left anterior descending artery lesion, emergency percutaneous coronary intervention (PCI), β-blocker, and angiotensin converting enzyme inhibitor/angiotensin receptor antagonist (ACEI/ARB) were statistically different between CRS1 and non-CRS1 groups (all P<0.05). Multivariate logistic regression showed that age, history of diabetes, Killip classification, reduced LVEF, reduced eGFR, hyponatremia, the left anterior descending artery lesionn, emergency PCI non-undergo, and β-blocker non-use were independent risk factors for CRS1 after AMI. Conclusions CRS1 is a common complication in AMI patients, which is associated with many factors. Our data suggest that patients with AMI should be more comprehensively assessed and monitored, thereby preventing the occurrence of CRS1. Key words: Myocardial infarction/CO; Heart failure/CO; Kidney failure/CO; Syndrome; Risk factors