Valproate and Retinoic Acid in Combination With Decitabine in Elderly Nonfit Patients With Acute Myeloid Leukemia: Results of a Multicenter, Randomized, 2 × 2, Phase II Trial

Michael Lübbert,Olga Grishina,Claudia Schmoor,R F Schlenk,Edgar Jost,Martina Crysandt,Michael Heuser,Felicitas Thol,Helmut R. Salih,Marcus M. Schittenhelm,Ulrich Germing,Andrea Kuendgen,Katharina Götze,Hans Walter Lindemann,Carsten Müller-Tidow,Gerhard Heil,Sebastian Scholl,Gesine Bug,Carsten Schwaenen,Aristoteles Giagounidis,Andreas Neubauer,Jürgen Krauter,Wolfram Brugger,Maike de Wit,Ralph Wäsch,Heiko Becker,Annette M. May,Justus Duyster,Konstanze Döhner,Arnold Ganser,Björn Hackanson,Hartmut Döhner

Valproate and Retinoic Acid in Combination With Decitabine in Elderly Nonfit Patients With Acute Myeloid Leukemia: Results of a Multicenter, Randomized, 2 × 2, Phase II Trial

2019

PURPOSEDNA-hypomethylating agents are studied in combination with other epigenetic drugs, such as histone deacetylase inhibitors or differentiation inducers (eg, retinoids), in myeloid neoplasias. ...

Keywords:

Cancer research
Epigenetics
Histone deacetylase
Pathology
Retinoic acid
Myeloid
Medicine
Myeloid leukemia
Decitabine

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