In vitro basis for schedule-dependent interaction between gemcitabine and topoisomerase-targeted drugs in the treatment of colorectal cancer

A hollow milling tool (1) for the production of substantially hollow cylindrical depressions in human or animal tissue, in particular for the production of tissue pillars which are removed at a harvest location, transported to a defect location and implanted there, has teeth (2) for the ablation of tissue which are arranged at the distal end of the milling tool at the end side. Furthermore, the milling tool has passages for transporting a cooling fluid to a cooling region of the milling tool lying near the distal end during the ablation of tissue.