monoclonal anti-IL-1R1 human therapeutic

n isolated human antibody that specifically binds to the receptor type 1 interleukin-1 or a fragment antigen binding thereof, comprising: a. gines structural human heavy chain, a region of the heavy chain CDR1, wherein the CDR1comprende the amino acid sequence of SEQ ID NO: 63; CDR2 region of the heavy chain CDR2 region in the chelates comprising the amino acid sequence of SEQ ID NO: 66; a CDR3 region of cadenapesada, wherein the CDR3 region comprises the amino acid sequence of SEQ ID NO: 69; b. structural ines human light chain, a region of the light chain CDR1, wherein the region CDR1comprende the amino acid sequence of SEQ ID NO: 71; CDR2 region of the light chain, wherein laregion CDR2 comprising the amino acid sequence of SEQ ID NO: 73; a CDR3 region of the light chain, wherein the CDR3 region comprises the amino acid sequence of SEQ ID NO: 75.