Local mucosal immune responses were induced by recombinant vaccinal Escherichia coli which was surface dispalyed SLT-IIeB

To study whether vaccinal bacteria can stimulate high level of mucous specific SIgA,recombinant Escherichia coli PZBSPAX which surface dispalyed was oral administered into 1 and 15 day-old mice.After 10?d,15?d and 30?d,serum and mucosal washes were collected to detect antigen specific IgG and IgA antibody levels by using ELISA,and the data show that mucosal(including fecal and vaginal washes) IgA levels and serum IgG antibody titer were vigorously increased.Tie results showed that the recombinant PZBSPAX could act as oral vaccineto active the mucosal immune response and system humoral immune response.