Atividade antibacteriana de novas 2-Amino-1,4-Naftoquinonas

Several compounds that have 1,4-naphthoquinone skeleton are widely studied, mainly in the development of new drugs. Its biological activity is attributed to its ability to act in the transport of electrons and, from the generation of reactive oxygen species (ROS) such as hydrogen peroxide, hydroxyl radicals and superoxide radical anions, induce oxidative stress in cells. This process is irreversible as it causes permanent damage to nucleic acids and essential proteins. Moreover, the incorporation of N-atom on C-2 and C-3 of 1,4-naphtoquinone structure has led to compounds with diversified biological activities including the antibacterial. In this work, a series of 2-amino-1,4-naphthoquinones were synthesized, and their antibacterial activity was evaluated against nine bacterial strains including Gram-positive and Gram-negative.