Rat Hepatic DNA Damage Induced by 1,2,3-Trichloropropane

1,2,3-Trichloropropane (TCP) is used as an industrial solvent and as an intermediate in pesticide and polysulfide rubber manufacturing. It is structurally similar to other halogenated alkanes with known carcinogenic potential (1,2- dibromoethane and 1,2-dibromo-3-chloropropane). Preliminary evidence from a chronic bioassay study conducted by the National Toxicology Program indicates that TCP administration results in an increased incidence of tumors in both male and female F-344 rats and B6C3F1 mice (Mahmood et al.,1988).