Furosemide Mediated Elevations of Thyroid Iodide Uptake in the Rat

Conclusions1. Intraperitoneal injection of 20 mg of furosemide/kg/day can cause an increased excretion of iodide in rats, thereby lowering their iodide pool.2. The effect of furosemide on the iodide pool is seen to occur after long-term use–a 2-wk course of the diuretic was given.3. Supplemental dietary iodide will not prevent the effect of furosemide, but furosemide will still cause a loss of iodide, and thereby significantly elevate the radioactive iodide uptakes when compared to controls.