Variations in the Number of Regulatory T Cells (CD4+ CD25 + ) in Patients with Breast Cancer during Herceptin Therapy

We studied the effect of Herceptin therapy on the population composition of lymphocytes and percentage of CD4+CD25+ cells (regulatory T cells) in breast cancer patients. Herceptin treatment decreased the number of “professional” T suppressors (CD4+CD25+ cells and regulatory T cells) in the peripheral blood.