Comparison of CLSI broth macrodilution and microdilution methods for echinocandin susceptibility testing of 5 Candida species.

Abstract In order to compare the Clinical and Laboratory Standards Institute (CLSI) broth macrodilution and microdilution methods of susceptibility testing for echinocandins and yeast, 55 strains of Candida representing 5 species were tested using the CLSI-recommended broth macro- and microdilution methods. Small (1–3 log 2 ) but potentially important method-, species-, and drug-dependent differences in MICs were observed.