Radioprotective effect of hydroxy phenylethanolamine phenolic hydroxyl esters

: Experiments are carried out on 3000 mice, irradiated in dose 8 Gy (LD97/30). A number of phenolic hydroxyl esters of phenylephrine, norphenylephrine and epinephrine has the high RPE (70-100%) within 1 h before irradiation. 3-esters of 3-hydroxy phenylethanolamines are active in small doses (19-50 mumol/kg) and protect per os too. RPE of 3-benzoylphenylephrine realizes via alpha 1-adrenoreceptors.