[Breast lesions with moderate and high risk of invasive breast cancer--incidence and some particularities].

INTRODUCTION: According to the American College of Pathologists consensus statement proliferative lesions with atypia are benign breast conditions with moderately increased breast cancer risk. Ductal carcinoma in-situ and lobular carcinoma in-situ are described as conditions associated with high risk of invasive breast cancer. AIM: Aim of the following investigation was to analyze the incidence of moderate and high risk lesions leading to invasive breast cancer among the central-north Bulgaria women's population and to access by immunohistological method some of their phenotype biological characteristics. PATIENTS AND METHODS: Six hundred and twenty one clinical cases, histologically verified as benign breast disorders were reviewed in a retrospective study. In 18 of all revealed cases atypical hyperplasia was found. The remaining 591 patients were with benign breast lesions with non-increased and slightly increased risk of invasive breast cancer. Carcinoma in-situ was obtained in 12 cases for the studied period. CD34 and Ki-67 immunostaining was preformed and evaluated. RESULTS AND DISCUSSION: Incidence of benign breast lesions with moderate and high risk was 2.9%, lower than data in literature. Assessment of CD34 positive fibrocytes might play an important role in breast lesion differential diagnosis.