Effect of metformin versus insulin on maternal weight gain in women with gestational diabetes mellitus: A randomized controlled clinical trial

Aim: The aim of the study was to compare maternal weight gain in gestational diabetes mellitus (GDM) treated with metformin or insulin.Materials and Methods: The study included 124 women with GDM, 62 of them treated with metformin, and 62 with insulin, from the outpatient clinic of Ain Shams University Maternity Hospital.Results: The groups were comparable in age, BMI, gestational age at time of recruitment and positive family history of diabetes. Rate of maternal weight gain per week was statistically significantly lower in the metformin group compared to the insulin group. Average rate of maternal weight gain per week was 562.7 ± 111.7 gm/week in insulin group and 453.2 ± 99.58 gm/week in metformin group.Conclusion: Metformin in women with GDM can cause less rate of maternal weight gain rather than insulin in women with GDM. While has no impact on other pregnancy maternal or neonatal outcome.