Structural and conformational studies on 3,3′-bis [1,3-thiazolidin-4-one] derivatives with biological activity

Abstract 3,3′-(1,2-ethanediyl)bis[2-substituted-1,3-thiazolidin-4-one] derivatives display different biological activities depending on the configuration of the 2,2′ centers and on the substitution at C2, C2′. In this context, 3,3′-(1,2-ethanediyl)bis[2-(2′-(5′-methyl)thienyl)-1,3-thiazolidin-4-one] ( 6b ) and 3,3′-(1,2-ethanediyl)bis[2-(3′-pyridyl)-1,3-thiazolidin-4-one] ( 8b ) have been prepared. Their structural and conformational features, which can be related to the biological activity, have been investigated by X-ray diffraction and molecular modeling techniques.