An ultrasonic prostate cancer diagnosis targeting reagent and a preparing method thereof

The invention relates to an ultrasonic prostate cancer diagnosis targeting reagent and a preparing method thereof. The targeting reagent is perfluoro bromooctane nanoparticles modified by an EpDT3 aptamer. The EpDT3 aptamer is selected from: a) EpDT3-SH that is 5'-GCGACUGGUUACCCGGUCG-(CH2)6-SH-3' and is modified by 2'-fluoropyrimidine; or b) EpDT3-NH2 that is 5'-NH2-spacer-GCGACUGGUUACCCGGUCGinvertedT-3' and is provided with 2'-fluoropyrimidine and 3'-inverted T, wherein the 5'-amino is connected through hexaethylene glycol. The targeting reagent modified by the EpDT3 aptamer can be retained on tumor vascular beds and has excellent targeting property and significantly enhanced developing effects.