Palladium-Catalyzed Cross-Coupling between 8-Substituted 6-Thiophenyl­purines and Boronic Acids

Roxane Vabre,Julien Couradin,Delphine Naud-Martin,Michel Legraverend,Sandrine Piguel

Palladium-Catalyzed Cross-Coupling between 8-Substituted 6-Thiophenylpurines and Boronic Acids

2014

Roxane Vabre
Julien Couradin
Delphine Naud-Martin
Michel Legraverend
Sandrine Piguel

A palladium(II)-catalyzed, copper(I)-mediated Liebeskind–Srogl cross-coupling for the C-6 arylation/alkenylation on purine scaffold is reported. Various boronic acids reacted readily with 8-substituted 6-thiophenylpurines.

Keywords:

Photochemistry
Purine
Copper
Purine metabolism
Catalysis
Palladium
Organic chemistry
Sulfur
Chemistry
purine derivative

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Palladium-Catalyzed Cross-Coupling between 8-Substituted 6-Thiophenyl­purines and Boronic Acids

Palladium-Catalyzed Cross-Coupling between 8-Substituted 6-Thiophenylpurines and Boronic Acids