Malignant tumors of the central nervous system associated with familial polyposis of the colon: report of two cases.

Turcot syndrome is the association between familial adenomatous polyposis and brain tumors like medulloblastoma, malignant glioma. It was first reported by Canadian surgeon Jacques Turcot (1914- ) et al in 1959 and hence carries the first author's name.[1] The genetic basis of Turcot syndrome is uncertain.The gene most likely to be involved is APC gene in chromosome 5q.[2] However, the syndrome has been claimed to be linked to various mutations in a number of genes.