A Reappraisal of Cystic Fibrosis

Danes and Bearn1 have reported increased metachromasia in cultured skin cells in cystic fibrosis (CF), and their observations have been confirmed recently by Matalon and Dorfman2, who find that the acidic mucopolysaccharides are of an apparently normal type in these cells, although they are present at two to five times the usual level.