Skin Barrier-Related Pathogenesis of Atopic Dermatitis

Skin barrier is composed of corneocytes, stratum corneum intercellular lipids, corneodesmosomes, and tight junctions. Atopic dermatitis (AD) begins with impairment of skin barrier function. If damage to the skin barrier persists, external antigens can easily penetrate into the skin and become sensitized. Inflammation of the skin further damages the skin barrier, making it easier to develop allergic diseases such as food allergy, asthma, and allergic rhinitis. Maintaining and preserving skin barrier function treats AD and prevents atopic march.