Современные представления о патогенезе гемофилической артропатии

The main manifestations of haemophilia are bleedings in the major joints. Haemarthrosis triggers the pathogenetic cascade, which can lead to development of haemophilic arthropathy. The blood has a negative effect on the status of the articular cartilage and synovial membrane. Numerous studies demonstrate the key role of prophylactic treatment in prevention of haemophilic arthropathy. The dose of coagulation factor can be corrected with consideration for its pharmacokinetic characteristics, so that the activity of the deficient factor is not reduced below 1% for a long time, in order to prevent spontaneous bleedings and development of arthropathy.