The Inhibitory Action of Fluconazole on Yeast-to-Mycelial Phase Conversion in Candida albicans

The ability of fluconazole, a bis-triazole antifungal agent, to inhibit conversion of Candida albicans from the yeast (Y) to the pathogenic mycelial (M) form was studied under various in vitro cultural conditions. In growth-supporting media, fluconazole was able to inhibit Y to M conversion of the test organism at concentrations below those required to inhibit Y phase growth. Under nongrowth-supporting conditions (N-acetylglucosamine solution) fluconazole had only a small effect on Y to M conversion.