Study on the Structure and the Solute Transport Characteristics of Hemodialysis Membrane.

The mechanism of structure formation and the characteristic of solute permeation on regenerated cellulose hollow fiber membrane for hemodialysis are discussed.Coagulation process of cuprammonium cellulose solution is dominated by the interfacial potential, caused at the interface between cellulose solution and coagulant solution, and thus the coagulation mechanism can be classified into three types.They are copper ion removal type, Normann reaction type and ammonia removal type. According to these dynamics it is possible to generate the various type of membrane pore structure. And the characteristics of solute permeation of the membrane is to be controlled by the pore structure of the membrane.Thus the characteristics of solute permeation is to be controlled by the coagulation process.And how to characterize the generated pore structure of the membrane is indispensable for the membrane architecture. Validity of the image analysis of SEM for the characterization of pore structure of the membrane is shown. Futhermore, SAXS analysis has been developed and studied for the analysis of pore structure, the possibility of this method is also discussed.