Association between the adiposity and early-stage atherosclerotic cardiovascular disease.

Objective To estimate more predictive indexes of body fat, including body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) or body fat mass (BFM), to the occurrence of early-stage atherosclerotic cardiovascular disease in person without clinical symptoms. Methods 649 cases aged 55 ±11 yrs were selected and examined with the four measurement indexes of body fat. The occurrence of early-stage atherosclerotic cardiovascular disease was estimated by the echocardiography and blood test. Results These four measurements of body fat had positive relations with SBP, DBP, blood glucose, TG and Apo B, while had negative relations with HDL-C and Apo A1. BMI, WC, WHR and BFM were strongly associated with the occurrence of early-stage atherosclerotic cardiovascular disease. BFM had the closest relation with the occurrence of carotid intima-media thickness (OR=1.98, 95%CI: 1.44-2.57). WHR had the closest relation with low degree inflammation (OR=1.74, 95%CI: 1.43-2.10). Conclusion BFM shows the best association with early -stage atherosclerosis. Our finding suggests that BFM can be used as a complementary measurement to identify the occurrence of atherosclerotic cardiovascular disease in adult subjects.