A Framework for Iterative Reconstruction in Phase-Contrast Computed Tomography Dedicated to the Breast

We present the implementation of a computed tomography (CT) iterative reconstruction strategy developed within the SYRMA-CT project for in vivo phase-contrast CT of uncompressed breast, ongoing at the ELETTRA synchrotron radiation facility (Trieste, Italy). Propagation-based phase-contrast imaging exploits the high spatial coherence of the monoenergetic laminar X-ray beam, as well as the large object-to-detector distance and the use of a Pixirad-8 high-resolution photon-counting CdTe detector. The signal in projection views depends on the X-ray absorption as well as on the phase shift introduced by the breast tissue in the beam path. A phase retrieval algorithm allowed recovering the projected 2-D phase information of the irradiated tissue layer, which was input to the CT reconstruction; then, the breast slices were reconstructed via a simultaneous algebraic reconstruction technique algorithm. Our iterative reconstruction—coupled with a filtering process for reducing the noise level and ring artifacts while preserving edges sharpness—showed better image quality than conventional filtered back projection (FBP) reconstruction. This phantom study showed that our iterative reconstruction produced images with higher contrast-to-noise ratio and spatial resolution than those obtained with FBP. Finally, the developed algorithm removed ring-like artifacts, without worsening the image quality.