Oleophylic Nanospheres Self-Assembly by Emulsion Technique Utilizing the Automatic Nanoscalar Interfacial Alternation (ANIAE).

Background The administration of many pharmaceutical active ingredients is often performed by the injection of an aqueous-based solution, numerous active ingredients are however, insoluble in water, which complicates their administration and restricts their efficacy. Objective The current solutions are hindered by both a time-consuming manufacturing process and are not suitable for hydrophilic and hydrophobic materials. Method Emulsions of oleophilic active ingredients and polyprotein microspheres are an important step to overcome insolubility issues. Results Polyprotein microspheres offer a versatile modifiable morphology, thermal responsivity, and size variation, which allows for the protection and release of assembled biomaterials. In addition, nanospheres present promising cell phagocytosis outcomes in vivo. Conclusion In this research, a reproducible multifunctional approach to assemble nanospheres in one step using a technique termed "automatic nanoscalar interfacial alternation in emulsion" (ANIAE) was developed, incorporating a thermally controlled release mechanism for the assembled target active ingredients. These results demonstrate a viable, universal, multifunctional principal for the pharmaceutical industry.